House begins a detox program at Mayfield Psychiatric Hospital to get the vicodin out of his system in an attempt to control his hallucinations. House plans to leave the treatment facility once he is clean, but he is strong-armed into staying by his attending physician, Dr. Darryl Nolan (guest star Andre Braugher). Dr. Nolan agrees to write a recommendation to reinstate House's medical license only if House agrees to further treatment.
When House is moved to a new ward in the hospital, he develops a close relationship with his new roommate, Alvie (guest star Lin-Manuel Miranda), and Lydia (guest star Franka Potente), a frequent visitor who helps House bend the rules. House asks Alvie to help him uncover incriminating information about Dr. Nolan that would allow him to blackmail his way out of the treatment center and convinces Lydia to loan him her car to sneak out a delusional patient in an attempt by House to undermine Dr. Nolan's course of treatment. But when devastating events ensue, House is humbled into reluctantly accepting help in "Broken," the special two-hour season premiere episode of HOUSE airing Monday, Sept. 21